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Patients who previously suffered from heart disease, even after recovery can be faced with their consequences. So, some people after some time after the disease in the walls and valves of the heart can start to form calcium deposits. Mineralization of the tissues can be caused, for example, ischemia. Still was not accurate information that leads to calcification of the heart and how to influence it. At the moment medications from calcification does not exist.
This problem was carried out by scientists from the University of California (University of California) led by Arjuna Debom (Arjun Deb). The scientific group began their study by finding the cells responsible for the calcification of heart tissues. As it was previously known that calcification, fibrosis, and tissue damage are closely linked, Arjun, deb and his colleagues hypothesized that the formation of calcium sediments can participate fibroblasts located in the heart. “In peacetime,” their main task — the regeneration of tissues and formation of scars. Scientists decided to test the behavior of cardiac fibroblasts after heart receives any damage.
To do this, the researchers put a genetic label on cardiac fibroblasts mice and then observe how the process of mineralization of tissues after damage. After this tissue is implanted under the skin of healthy mice, where the process continued. The scientists noted that in laboratory conditions, human cardiac fibroblasts respond to damage as well as mouse.
In the next step the group made by Arjun DeBa drew attention to the protein ENPP1, which in large quantities is produced by the fibroblasts of the heart during injury, and hypothesized that it is responsible for the formation of deposits. The researchers decided to try to “undo” the calcification of tissues. When they were introduced into samples of certain molecules known for their ability to suppress the activity of ENPP1, sediment was less than 50%. Therapy with inhibitors of bone resorption by etidronate gave results in complete absence of calcium deposits after damage to heart tissue.
According to made by Arjun DeBa, now he and his colleagues find out, how often calcification occurs this way and can I stop its process in other tissues, inhibiting the action ENPP1. The researchers also plan to find out. is it possible to stop the formation of deposits in blood vessels or reversing calcification reversed — because the molecules have only worked in that case, if the injection occurred before the injury.