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Debate about whether useful or harmful sugar substitutes, being long. Often in discussions it is mentioned aspartame. A team of researchers from the Massachusetts hospital (Massachusetts General Hospital), located at Harvard medical school (Harvard Medical School) found that this sugar substitute does not help people to lose weight, but on the contrary contributes to weight gain. This is because one of the breakdown products of aspartame, phenylalanine, interferes with enzyme, preventing the development of metabolic syndrome.
A research group headed by Professor Richard Hodin (Richard.). He explained that the sugar substitutes used by people who want to lose weight. They think that in this way move towards a healthy lifestyle, but it’s not. According to Professor Khodina, studies in mice show that aspartame does not actually improves and worsens the situation. It blocks the intestinal alkaline phosphatase (IAP) — and this enzyme, according to previously published works, prevents the development of diabetes, obesity and metabolic syndrome.
In the first stage of experiments, the scientists found that the activity of the intestinal alkaline phosphatase is reduced if you add it to a solution containing a quantity of beverage sweetened with aspartame. If the solution with a drink instead of aspartame present in the sugar — intestinal alkaline phosphatase remained as active as he was. Main place of production of this enzyme — the small intestine, and when the researchers did the mice injections with a solution of aspartame in this area, the activity of the enzyme was significantly reduced. A solution containing aspartame instead of salt, this effect had not.
To understand the mechanism of aspartame more, scientists conducted experiments on four groups of mice monitored for 18 weeks. Group 1 ate normally and drank water, sweetened with aspartame. Group 2 under normal diet, consume only normal water. The diet of individuals from groups 3 and 4 contained a sick amount of fat, but mice from group 3 drank water with aspartame, and group 4 — plain water.
After 18 weeks, the researchers made measurements — weighed the mice and took their tests. The weight of mice from groups 1 and 2 practically does not differ, but individuals of the 3 groups gained more weight than their “colleagues” from the group 4. As for the indicators of the analysis of blood, regardless of diet, those mice that drank water with aspartame the sugar level in the blood, and tumor necrosis factor alpha (protein — a biomarker of inflammation) was higher. Therefore, aspartame had a negative impact on the health of experimental animals.