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A group of researchers from Baylor medical College (Baylor College of Medicine) published a paper, the results of which can be thought-provoking for people who fly often in business trips. Or jet lag syndrome jet lag, experts say, can cause insomnia and headache, but obesity, a liver disease if it becomes chronic. Experiments involving mice showed that a permanent disorder of daily rhythms leads to weight gain and accumulation of fat in the liver, and some individuals have higher levels of inflammation in the body, and in turn, this increase led to the development of liver cancer.
The lead author of the study was to David Moore (David Moore), and the experiments were conducted in the laboratory of associate Professor Lonna Fu (Loning Fu). Professor Moore said that in recent years the number of patients with liver cancer is increasing, and in some patients the disease evolves from fatty hepatosis, bypassing the stage of liver cirrhosis. In mice, the process is similar to a human. During the experiments, scientists simulated the situation of chronic jetlag in experimental animals, while people fed the mice a healthy diet without excess fat. The light the researchers included a schedule, which changed weekly, and after a while they noted that the mice gain weight. Further examination showed that the animals had a metabolic disorder of the liver, leading to accumulation of fat. Also individuals, which were monitored, produce more bile acids, high levels of which, according to previous research, is associated with an increased risk of developing cancer.
Every time, when violated daily rhythms in the body start working two receptor-regulator of metabolism. Mice who developed liver cancer was lower than the protein concentration FXR, which controls the amount of bile acids in the liver. On the other hand, those individuals who have the organisms was less than the other protein CAR, less likely to develop cancer.
The researchers noted that both of these receptors are found in the human body, thus, the results may apply to humans. In a next step, the scientists plan to study how we can use their discovery to create new therapies.