Marine sponges of the far Eastern scientists have uncovered new secrets of cancer

To synthesize new anti-cancer agent from marine sponges have been a scholar, far Eastern Federal University. The authors of the achievements the staff of the Department of organic chemistry School of natural Sciences — believe that their development can significantly increase the chances of cancer patients with conservative treatment.


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As it became known “MK”, the University was able to obtain in the laboratory a new synthetic derivative taskplugin — substances from marine sponges, with an active anti-tumor properties. This substance can inhibit a special enzyme (cyclin-dependent kinase 4), which provides rapid and uncontrolled division of cancer cells. According to experts, although taskplugin has a number of unique properties, it is not currently used to fight cancer because of its high toxicity. The aim of the study of the far Eastern specialists “improvement” of its structure to increase activity and decrease harm to human body. The tests have given promising results: after testing the capabilities of the new tools on the cells of cervical cancer and monocytic leukemia, scientists have found that a new compound for its activity in 2-3 times exceeds the known science at the moment taskplugin — in addition, it is less toxic. The results of the research suggest that with the opening will be able to significantly improve the already widely used drugs.

— Marine sponges are producers of a large number of compounds with diverse structure and high biological activity, says associate Professor of organic chemistry School of natural Sciences FEFU Maxim Zhidkov. — This determines the interest in their study. Derived faceposing is still at a very early stage of a long process of testing.

By the way, the sponge is not the only promising “experimental” far East scientists are able in the future to improve anticancer therapy. In the study of new anti-cancer substances scientists first managed to synthesize another “useful” link (6-exofusion): source for him was the Indigo dye. In addition, Department staff conducted research and other well-known natural compounds (Korobitsina (triptycene) contained in some terrestrial plants and has anti-inflammatory and antimicrobial action.

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